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Inflammation

Myeloperoxidase (MPO)

  1. da Cunha NV, Pinge-Filho P, Panis C, Silva BR, Pernomian L, Grando MD, Cecchini R, Bendhack LM, Martins-Pinge MC. Decreased endothelial nitric oxide, systemic oxidative stress, and increased sympathetic modulation contribute to hypertension in obese rats. Am J Physiol Heart Circ Physiol. 2014 May 15;306(10):H1472-80. doi: 10.1152/ajpheart.00520.2013. Epub 2014 Mar 14. PubMed PMID: 24633548.

  2. Dinh QN, Drummond GR, Sobey CG, Chrissobolis S. Roles of inflammation, oxidative stress, and vascular dysfunction in hypertension. Biomed Res Int. 2014;2014:406960. doi: 10.1155/2014/406960. Epub 2014 Jul 20. Review. PubMed PMID: 25136585; PubMed Central PMCID: PMC4124649.

  3. Floras JS. Epinephrine and the genesis of hypertension. Hypertension. 1992 Jan;19(1):1-18. Review. PubMed PMID: 1309718.

  4. Gil-Cardoso K, Ginés I, Pinent M, Ardévol A, Terra X, Blay M. A cafeteria diet triggers intestinal inflammation and oxidative stress in obese rats. Br J Nutr. 2017 Jan;117(2):218-229. doi: 10.1017/S0007114516004608. Epub 2017 Jan 30. PubMed PMID: 28132653.

  5. Heinecke JW, Goldberg IJ. Myeloperoxidase: a therapeutic target for preventing insulin resistance and the metabolic sequelae of obesity? Diabetes. 2014 Dec;63(12):4001-3. doi: 10.2337/db14-1273. PubMed PMID: 25414015; PubMed Central PMCID: PMC4238000.

  6. Payne RL, Southern LL. Changes in glutathione peroxidase and tissue selenium concentrations of broilers after consuming a diet adequate in selenium. Poult Sci. 2005 Aug;84(8):1268-76. PubMed PMID: 16156211.

  7. Shiba Y, Kinoshita T, Chuman H, Taketani Y, Takeda E, Kato Y, Naito M, Kawabata K, Ishisaka A, Terao J, Kawai Y. Flavonoids as substrates and inhibitors of myeloperoxidase: molecular actions of aglycone and metabolites. Chem Res Toxicol. 2008 Aug;21(8):1600-9. doi: 10.1021/tx8000835. Epub 2008 Jul 12. PubMed PMID: 18620432.

  8. Tiyerili V, Camara B, Becher MU, Schrickel JW, Lütjohann D, Mollenhauer M, Baldus S, Nickenig G, Andrié RP. Neutrophil-derived myeloperoxidase promotes atherogenesis and neointima formation in mice. Int J Cardiol. 2016 Feb 1;204:29-36. doi: 10.1016/j.ijcard.2015.11.128. Epub 2015 Nov 22. PubMed PMID: 26655530.

  9. Wang Q, Xie Z, Zhang W, Zhou J, Wu Y, Zhang M, Zhu H, Zou MH. Myeloperoxidase deletion prevents high-fat diet-induced obesity and insulin resistance. Diabetes. 2014 Dec;63(12):4172-85. doi: 10.2337/db14-0026. Epub 2014 Jul 14. PubMed PMID: 25024373; PubMed Central PMCID: PMC4238009.

  10. da Cunha NV, Pinge-Filho P, Panis C, Silva BR, Pernomian L, Grando MD, Cecchini R, Bendhack LM, Martins-Pinge MC. Decreased endothelial nitric oxide, systemic oxidative stress, and increased sympathetic modulation contribute to hypertension in obese rats. Am J Physiol Heart Circ Physiol. 2014 May 15;306(10):H1472-80. doi: 10.1152/ajpheart.00520.2013. Epub 2014 Mar 14. PubMed PMID: 24633548.

  11. Dinh QN, Drummond GR, Sobey CG, Chrissobolis S. Roles of inflammation, oxidative stress, and vascular dysfunction in hypertension. Biomed Res Int. 2014;2014:406960. doi: 10.1155/2014/406960. Epub 2014 Jul 20. Review. PubMed PMID: 25136585; PubMed Central PMCID: PMC4124649.

  12. Floras JS. Epinephrine and the genesis of hypertension. Hypertension. 1992 Jan;19(1):1-18. Review. PubMed PMID: 1309718.

Lp-PLA2 Activity

  1. Bale BF, Doneen AL. The Bale/Doneen Method: Paradigm Shift in CVD Prevention. Preceptorship Course; 2018 March 09; Las Vegas, Nevada, United States of America.

  2. Boillot A, Demmer RT, Mallat Z, Sacco RL, Jacobs DR, Benessiano J, Tedgui A, Rundek T, Papapanou PN, Desvarieux M. Periodontal microbiota and phospholipases: the Oral Infections and Vascular Disease Epidemiology Study (INVEST). Atherosclerosis. 2015 Oct;242(2):418-23. doi: 10.1016/j.atherosclerosis.2015.07.039. Epub 2015 Jul 22. PubMed PMID: 26282947; PubMed Central PMCID: PMC4862208.

  3. Garg PK, Norby FL, Polfus LM, Boerwinkle E, Gibbs RA, Grove ML, Folsom AR, Garimella PS, Matsushita K, Hoogeveen RC, Ballantyne CM. Lipoprotein-associated phospholipase A2 and risk of incident peripheral arterial disease: Findings from The Atherosclerosis Risk in Communities study (ARIC). Atherosclerosis. 2018 Jan;268:12-18. doi: 10.1016/j.atherosclerosis.2017.11.007. Epub 2017 Nov 14. PubMed PMID: 29169030.

  4. Siddiqui MK, Kennedy G, Carr F, Doney ASF, Pearson ER, Morris AD, Johnson T, McLaughlin MM, Williams RE, Palmer CNA. Lp-PLA2 activity is associated with increased risk of diabetic retinopathy: a longitudinal disease progression study. Diabetologia. 2018 Apr 6. doi: 10.1007/s00125-018-4601-7. [Epub ahead of print] PubMed PMID: 29623345.

  5. Silva IT, Mello AP, Damasceno NR. Antioxidant and inflammatory aspects of lipoprotein-associated phospholipase A₂ (Lp-PLA₂): a review. Lipids Health Dis. 2011 Sep 28;10:170. doi: 10.1186/1476-511X-10-170. Review. PubMed PMID: 21955667; PubMed Central PMCID: PMC3204246.

  6. Sofogianni A, Alkagiet S, Tziomalos K. Lipoprotein-associated Phospholipase A2 and Coronary Heart Disease. Curr Pharm Des. 2018;24(3):291-296. doi: 10.2174/1381612824666180111110550. PubMed PMID: 29332572.

High Sensitivity C-Reactive Protein (hs-CRP) & C-Reactive Protein (CRP)

  1. Alarcon G, Roco J, Medina M, Medina A, Peral M, Jerez S. High fat diet-induced metabolically obese and normal weight rabbit model shows early vascular dysfunction: mechanisms involved. Int J Obes (Lond). 2018 Jan 30. doi: 10.1038/s41366-018-0020-6. [Epub ahead of print] PubMed PMID: 29445240.

  2. Bale BF, Doneen AL. The Bale/Doneen Method: Paradigm Shift in CVD Prevention. Preceptorship Course; 2018 March 09; Las Vegas, Nevada, United States of America.

  3. Burmeister A, Assi LK, Ferro CJ, Hughes RG, Barnett AH, Bellary S, Cockwell P, Pratt G, Hutchison CA. The relationship between high-sensitivity CRP and polyclonal free light chains as markers of inflammation in chronic disease. Int J Lab Hematol. 2014 Aug;36(4):415-24. doi: 10.1111/ijlh.12159. Epub 2013 Nov 5. PubMed PMID: 24188493.

  4. Ebrahimi M, Heidari-Bakavoli AR, Shoeibi S, Mirhafez SR, Moohebati M, Esmaily H, Ghazavi H, Saberi Karimian M, Parizadeh SM, Mohammadi M, Mohaddes Ardabili H, Ferns GA, Ghayour-Mobarhan M. Association of Serum hs-CRP Levels With the Presence of Obesity, Diabetes Mellitus, and Other Cardiovascular Risk Factors. J Clin Lab Anal. 2016 Sep;30(5):672-6. doi: 10.1002/jcla.21920. Epub 2016 Feb 8. PubMed PMID: 26857805.

  5. Porcu M, Urbano MR, Verri WA Jr., Barbosa DS, Baracat M, Vargas HO, Machado RCBR, Pescim RR, Nunes SOV. Effects of adjunctive N-acetylcysteine on depressive symptoms: Modulation by baseline high-sensitivity C-reactive protein. Psychiatry Res. 2018 Mar 13. pii: S0165-1781(17)32039-5. doi: 10.1016/j.psychres.2018.02.056. [Epub ahead of print] PubMed PMID: 29605103.

  6. Severance EG, Gressitt KL, Stallings CR, Origoni AE, Khushalani S, Leweke FM, Dickerson FB, Yolken RH. Discordant patterns of bacterial translocation markers and implications for innate immune imbalances in schizophrenia. Schizophr Res. 2013 Aug;148(1-3):130-7. doi: 10.1016/j.schres.2013.05.018. Epub 2013 Jun 6. PubMed PMID: 23746484; PubMed Central PMCID: PMC3732507.

  7. Siegel D, Devaraj S, Mitra A, Raychaudhuri SP, Raychaudhuri SK, Jialal I. Inflammation, atherosclerosis, and psoriasis. Clin Rev Allergy Immunol. 2013 Apr;44(2):194-204. doi: 10.1007/s12016-012-8308-0. Review. Erratum in: Clin Rev Allergy Immunol. 2018 Mar 19;:. PubMed PMID: 22359071.

  8. Song B, Shu Y, Xu YN, Fu P. Plasma fibrinogen lever and risk of coronary heart disease among Chinese population: a systematic review and meta-analysis. Int J Clin Exp Med. 2015 Aug 15;8(8):13195-202. eCollection 2015. PubMed PMID: 26550243; PubMed Central PMCID: PMC4612928.

  9. Yunchun L, Yue W, Jun FZ, Qizhu S, Liumei D. Clinical Significance of Myeloid-Related Protein 8/14 as a Predictor for Biological Treatment and Disease Activity in Rheumatoid Arthritis. Ann Clin Lab Sci. 2018 Jan;48(1):63-68. PubMed PMID: 29530998.

Microalbumin/Creatinine

  1. Aslan O, Demir M, Koseoglu M. Kidney Injury Molecule Levels in Type 2 Diabetes Mellitus. J Clin Lab Anal. 2016 Nov;30(6):1031-1036. doi: 10.1002/jcla.21976. Epub 2016 May 2. PubMed PMID: 27132791.

  2. Aziz KM. Correlation of Urine Biomarkers: Microalbuminuria and Spot Urine Protein among Diabetic Patients. Application of Spot Urine Protein in Diabetic Kidney Disease, Nephropathy, Proteinuria Estimation, Diagnosing and Monitoring. Recent Pat Endocr Metab Immune Drug Discov. 2015;9(2):121-33. PubMed PMID: 26152133.

  3. Kim SG, Kim GS, Lee JH, Moon AE, Yoon H. The relationship between vitamin D and estimated glomerular filtration rate and urine microalbumin/creatinine ratio in Korean adults. J Clin Biochem Nutr. 2018 Jan;62(1):94-99. doi: 10.3164/jcbn.17-69. Epub 2017 Nov 28. PubMed PMID: 29371760; PubMed Central PMCID: PMC5773835.

  4. Levin A, Stevens L, McCullough PA. Cardiovascular disease and the kidney. Tracking a killer in chronic kidney disease. Postgrad Med. 2002 Apr;111(4):53-60. Review. PubMed PMID: 11985133.

  5. Tomura S, Kawada K, Saito K, Lin YL, Endou K, Hirano C, Yanagi H, Tsuchiya S, Shiba K. Prevalence of microalbuminuria and relationship to the risk of cardiovascular disease in the Japanese population. Am J Nephrol. 1999;19(1):13-20. PubMed PMID: 10085444.

ADMA & SDMA

  1. Al-Dashti YA, Holt RR, Stebbins CL, Keen CL, Hackman RM. Dietary Flavanols: A Review of Select Effects on Vascular Function, Blood Pressure, and Exercise Performance. J Am Coll Nutr. 2018 May 2:1-15. doi: 10.1080/07315724.2018.1451788. [Epub ahead of print] PubMed PMID: 29718795.

  2. Bale BF, Doneen AL. The Bale/Doneen Method: Paradigm Shift in CVD Prevention. Preceptorship Course; 2018 March 09; Las Vegas, Nevada, United States of America.

  3. Mommersteeg PM, Schoemaker RG, Eisel UL, Garrelds IM, Schalkwijk CG, Kop WJ. Nitric oxide dysregulation in patients with heart failure: the association of depressive symptoms with L-arginine, asymmetric dimethylarginine, symmetric dimethylarginine, and isoprostane. Psychosom Med. 2015 Apr;77(3):292-302. doi: 10.1097/PSY.0000000000000162. PubMed PMID: 25790241.

  4. Nishimoto M, Mizuno R, Fujita T, Isshiki M. Stromal interaction molecule 1 modulates blood pressure via NO production in vascular endothelial cells. Hypertens Res. 2018 Apr 25. doi: 10.1038/s41440-018-0045-1. [Epub ahead of print] PubMed PMID: 29695773.

  5. Santamaria, Pietro & Elia, Antonio & Serio, Francesco & Todaro, Enzo. (1999). A survey of nitrate and oxalate content in fresh vegetables. Journal of the Science of Food and Agriculture. 79. 1882 – 1888. 10.1002/(SICI)1097-0010(199910)79:13<1882::AID-JSFA450>3.0.CO;2-D.

  6. Tsikas D, Bollenbach A, Hanff E, Kayacelebi AA. Asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA) and homoarginine (hArg): the ADMA, SDMA and hArg paradoxes. Cardiovasc Diabetol. 2018 Jan 4;17(1):1. doi: 10.1186/s12933-017-0656-x. PubMed PMID: 29301528; PubMed Central PMCID: PMC5753492.

  7. Wang F, Xiong R, Feng S, Lu X, Li H, Wang S. Association of Circulating Levels of ADMA with Carotid Intima-Media Thickness in Patients with CKD: a Systematic Review and Meta-Analysis. Kidney Blood Press Res. 2018;43(1):25-33. doi: 10.1159/000486743. Epub 2018 Jan 23. PubMed PMID: 29393214.

F2- Isoprostane & F2- Isoprostane/Creatinine

  1. Bale BF, Doneen AL. The Bale/Doneen Method: Paradigm Shift in CVD Prevention. Preceptorship Course; 2018 March 09; Las Vegas, Nevada, United States of America.

  2. Carlström M, Persson AE, Larsson E, Hezel M, Scheffer PG, Teerlink T, Weitzberg E, Lundberg JO. Dietary nitrate attenuates oxidative stress, prevents cardiac and renal injuries, and reduces blood pressure in salt-induced hypertension. Cardiovasc Res. 2011 Feb 15;89(3):574-85. doi: 10.1093/cvr/cvq366. Epub 2010 Nov 19. PubMed PMID: 21097806.

  3. Devaraj S, Hirany SV, Burk RF, Jialal I. Divergence between LDL oxidative susceptibility and urinary F(2)-isoprostanes as measures of oxidative stress in type 2 diabetes. Clin Chem. 2001 Nov;47(11):1974-9. Erratum in: Clin Chem 2002 Jan;48(1):213. PubMed PMID: 11673365.

  4. Il’yasova D, Fontana L, Bhapkar M, Pieper CF, Spasojevic I, Redman LM, Das SK, Huffman KM, Kraus WE; CALERIE Study Investigators. Effects of 2 years of caloric restriction on oxidative status assessed by urinary F2-isoprostanes: The CALERIE 2 randomized clinical trial. Aging Cell. 2018 Apr;17(2). doi: 10.1111/acel.12719. Epub 2018 Feb 9. PubMed PMID: 29424490; PubMed Central PMCID: PMC5847862.

  5. Mezzetti A, Cipollone F, Cuccurullo F. Oxidative stress and cardiovascular complications in diabetes: isoprostanes as new markers on an old paradigm. Cardiovasc Res. 2000 Aug 18;47(3):475-88. Review. Erratum in: Cardiovasc Res. 2003 Mar;57(3):869. PubMed PMID: 10963721.

  6. Montuschi P, Barnes P, Roberts LJ 2nd. Insights into oxidative stress: the isoprostanes. Curr Med Chem. 2007;14(6):703-17. Review. PubMed PMID: 17346157.

  7. Patrignani P, Tacconelli S. Isoprostanes and other markers of peroxidation in atherosclerosis. Biomarkers. 2005 Nov;10 Suppl 1:S24-9. Review. PubMed PMID: 16298908.

  8. Roberts LJ, Morrow JD. Measurement of F(2)-isoprostanes as an index of oxidative stress in vivo. Free Radic Biol Med. 2000 Feb 15;28(4):505-13. Review. PubMed PMID: 10719231.

  9. Tacconelli S, Capone ML, Patrignani P. Measurement of 8-iso-prostaglandin F2alpha in biological fluids as a measure of lipid peroxidation. Methods Mol Biol. 2010;644:165-78. doi: 10.1007/978-1-59745-364-6_14. PubMed PMID: 20645173.

  10. Ward WF, Qi W, Van Remmen H, Zackert WE, Roberts LJ 2nd, Richardson A. Effects of age and caloric restriction on lipid peroxidation: measurement of oxidative stress by F2-isoprostane levels. J Gerontol A Biol Sci Med Sci. 2005 Jul;60(7):847-51. PubMed PMID: 16079206.

Creatinine, Urine, Random

  1. Hooman N, Otoukesh H, Safaii H, Mehrazma M, Shokrolah Y. Quantification of proteinuria with urinary protein to osmolality ratios in children with and without renal insufficiency. Ann Saudi Med. 2005 May-Jun;25(3):215-8. PubMed PMID: 16119522.

  2. Institute of Medicine. Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids. [Internet]. Washington, D.C.: National Academies Press; 2005. 941. Available from: https://www.nal.usda.gov/sites/default/files/fnic_uploads/energy_full_report.pdf. DOI: https://doi.org/10.17226/10490.

  3. Ran J, Ma J, Liu Y, Tan R, Liu H, Lao G. Low protein diet inhibits uric acid synthesis and attenuates renal damage in streptozotocin-induced diabetic rats. J Diabetes Res. 2014;2014:287536. doi: 10.1155/2014/287536. Epub 2014 Mar 13. PubMed PMID: 24772444; PubMed Central PMCID: PMC3976836.

  4. Tosato M, Marzetti E, Cesari M, Savera G, Miller RR, Bernabei R, Landi F, Calvani R. Measurement of muscle mass in sarcopenia: from imaging to biochemical markers. Aging Clin Exp Res. 2017 Feb;29(1):19-27. doi: 10.1007/s40520-016-0717-0. Epub 2017 Feb 7. Review. PubMed PMID: 28176249.

Homocysteine

  1. Brown JC, Strain JJ. Effect of dietary homocysteine on copper status in rats. J Nutr. 1990 Sep;120(9):1068-74. PubMed PMID: 2168945.

  2. Mann NJ, Li D, Sinclair AJ, Dudman NP, Guo XW, Elsworth GR, Wilson AK, Kelly FD. The effect of diet on plasma homocysteine concentrations in healthy male subjects. Eur J Clin Nutr. 1999 Nov;53(11):895-9. PubMed PMID: 10557004.

  3. Mietus-Snyder ML, Shigenaga MK, Suh JH, Shenvi SV, Lal A, McHugh T, Olson D, Lilienstein J, Krauss RM, Gildengoren G, McCann JC, Ames BN. A nutrient-dense, high-fiber, fruit-based supplement bar increases HDL cholesterol, particularly large HDL, lowers homocysteine, and raises glutathione in a 2-wk trial. FASEB J. 2012 Aug;26(8):3515-27. doi: 10.1096/fj.11-201558. Epub 2012 May 1. PubMed PMID: 22549511; PubMed Central PMCID: PMC3405270.

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