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Genes

ApoE- 2/2, 2/3, 3/3, 3/4, & 4/4

  1. Bale BF, Doneen AL. The Bale/Doneen Method: Paradigm Shift in CVD Prevention. Preceptorship Course; 2018 March 09; Las Vegas, Nevada, United States of America.

  2. Ban CX, Zhong L, Wang T, Zhu MJ, Wang JH, Zhang ZL, Wang Z, Su N, Liu YY, Shi YC, Xiao SF, Li X. Enhanced Diabetes Susceptibility in Community-Dwelling Han Elders Carrying the Apolipoprotein E 3/3 Genotype. PLoS One. 2016 Mar 21;11(3):e0151336. doi: 10.1371/journal.pone.0151336. eCollection 2016. PubMed PMID: 26998902; PubMed Central PMCID: PMC4801405.

  3. Castellanos-Tapia L, López-Alvarenga JC, Ebbesson SO, Ebbesson LO, Tejero ME. Apolipoprotein E isoforms 3/3 and 3/4 differentially interact with circulating stearic, palmitic, and oleic fatty acids and lipid levels in Alaskan Natives. Nutr Res. 2015 Apr;35(4):294-300. doi: 10.1016/j.nutres.2015.02.002. Epub 2015 Feb 14. PubMed PMID: 25727313.

  4. Fryer JD, Simmons K, Parsadanian M, Bales KR, Paul SM, Sullivan PM, Holtzman DM. Human apolipoprotein E4 alters the amyloid-beta 40:42 ratio and promotes the formation of cerebral amyloid angiopathy in an amyloid precursor protein transgenic model. J Neurosci. 2005 Mar 16;25(11):2803-10. PubMed PMID: 15772340.

  5. Hu J, Liu CC, Chen XF, Zhang YW, Xu H, Bu G. Opposing effects of viral-mediated brain expression of apolipoprotein E2 (apoE2) and apoE4 on apoE lipidation and Aβ metabolism in apoE4-targeted replacement mice. Mol Neurodegener. 2015 Mar 5;10:6. doi: 10.1186/s13024-015-0001-3. PubMed PMID: 25871773; PubMed Central PMCID: PMC4356137.

  6. Institute of Medicine. Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids. [Internet]. Washington, D.C.: National Academies Press; 2005. 941. Available from: https://www.nal.usda.gov/sites/default/files/fnic_uploads/energy_full_report.pdf. DOI: https://doi.org/10.17226/10490.

  7. Johnson LA, Zuloaga DG, Bidiman E, et al. ApoE2 Exaggerates PTSD-Related Behavioral, Cognitive, and Neuroendocrine Alterations. Neuropsychopharmacology. 2015;40(10):2443-2453. doi:10.1038/npp.2015.95.

  8. Kim YJ, Seo SW, Park SB, Yang JJ, Lee JS, Lee J, Jang YK, Kim ST, Lee KH, Lee JM, Lee JH, Kim JS, Na DL, Kim HJ. Protective effects of APOE e2 against disease progression in subcortical vascular mild cognitive impairment patients: A three-year longitudinal study. Sci Rep. 2017 May 15;7(1):1910. doi: 10.1038/s41598-017-02046-y. PubMed PMID: 28507298; PubMed Central PMCID: PMC5432504.

  9. Liu CC, Liu CC, Kanekiyo T, Xu H, Bu G. Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy. Nat Rev Neurol. 2013 Feb;9(2):106-18. doi: 10.1038/nrneurol.2012.263. Epub 2013 Jan 8. Review. Erratum in: Nat Rev Neurol. 2013. doi: 10.1038/nmeurol.2013.32. Liu, Chia-Chan [corrected to Liu, Chia-Chen]. PubMed PMID: 23296339; PubMed Central PMCID: PMC3726719.

  10. Meng FT, Zhao J, Fang H, Liu YJ. The influence of chronic stress on anxiety-like behavior and cognitive function in different human GFAP-ApoE transgenic adult male mice. Stress. 2015;18(4):419-26. doi: 10.3109/10253890.2015.1040986. Epub 2015 May 4. PubMed PMID: 25938810.

  11. Neuzil J, Christison JK, Iheanacho E, Fragonas JC, Zammit V, Hunt NH, Stocker R. Radical-induced lipoprotein and plasma lipid oxidation in normal and apolipoprotein E gene knockout (apoE-/-) mice: apoE-/- mouse as a model for testing the role of tocopherol-mediated peroxidation in atherogenesis. J Lipid Res. 1998 Feb;39(2):354-68. PubMed PMID: 9507996.

  12. Raber J. Role of Apolipoprotein E in Anxiety. Neural Plasticity. 2007;2007:91236. doi:10.1155/2007/91236.

  13. Shinohara M, Kanekiyo T, Yang L, Linthicum D, Shinohara M, Fu Y, Price L, Frisch-Daiello JL, Han X, Fryer JD, Bu G. APOE2 eases cognitive decline during Aging: Clinical and preclinical evaluations. Ann Neurol. 2016 Mar 2. doi: 10.1002/ana.24628. [Epub ahead of print] PubMed PMID: 26933942; PubMed Central PMCID: PMC5010530.

  14. Tácito LHB, Yamada LN, de Souza Pinhel MA, Yugar-Toledo JC, Souza DRS. Influence of Apolipoprotein E on the Lipid Profile and Postprandial Triglyceride Levels in Brazilian Postmenopausal Women With Artery Disease. Clin Med Insights Cardiol. 2017 Sep 21;11:1179546817731110. doi: 10.1177/1179546817731110. eCollection 2017. PubMed PMID: 28974920; PubMed Central PMCID: PMC5613840.

  15. Thompson PD, Tsongalis GJ, Seip RL, Bilbie C, Miles M, Zoeller R, Visich P, Gordon P, Angelopoulos TJ, Pescatello L, Bausserman L, Moyna N. Apolipoprotein E genotype and changes in serum lipids and maximal oxygen uptake with exercise training. Metabolism. 2004 Feb;53(2):193-202. PubMed PMID: 14767871.

  16. ​Verpillat P, Camuzat A, Hannequin D, Thomas-Anterion C, Puel M, Belliard S, Dubois B, Didic M, Lacomblez L, Moreaud O, Golfier V, Campion D, Brice A, Clerget-Darpoux F. Apolipoprotein E gene in frontotemporal dementia: an association study and meta-analysis. Eur J Hum Genet. 2002 Jul;10(7):399-405. PubMed PMID: 12107813.

  17. Zhang H, Reymer PW, Liu MS, Forsythe IJ, Groenemeyer BE, Frohlich J, Brunzell JD, Kastelein JJ, Hayden MR, Ma Y. Patients with apoE3 deficiency (E2/2, E3/2, and E4/2) who manifest with hyperlipidemia have increased frequency of an Asn 291–>Ser mutation in the human LPL gene. Arterioscler Thromb Vasc Biol. 1995 Oct;15(10):1695-703. PubMed PMID: 7583546.

Haptoglobin Gene

  1. Bale BF, Doneen AL. The Bale/Doneen Method: Paradigm Shift in CVD Prevention. Preceptorship Course; 2018 March 09; Las Vegas, Nevada, United States of America.

  2. Farid N, Inbal D, Nakhoul N, Evgeny F, Miller-Lotan R, Levy AP, Rabea A. Vitamin E and diabetic nephropathy in mice model and humans. World J Nephrol. 2013 Nov 6;2(4):111-24. doi: 10.5527/wjn.v2.i4.111. Review. PubMed PMID: 24255894; PubMed Central PMCID: PMC3832867.

  3. Institute of Medicine. Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids. [Internet]. Washington, D.C.: National Academies Press; 2005. 941. Available from: https://www.nal.usda.gov/sites/default/files/fnic_uploads/energy_full_report.pdf. DOI: https://doi.org/10.17226/10490.

  4. Márquez L, Shen C, Cleynen I, De Hertogh G, Van Steen K, Machiels K, Perrier C, Ballet V, Organe S, Ferrante M, Henckaerts L, Galicia G, Rutgeerts P, Ceuppens JL, Vermeire S. Effects of haptoglobin polymorphisms and deficiency on susceptibility to inflammatory bowel disease and on severity of murine colitis. Gut. 2012 Apr;61(4):528-34. doi: 10.1136/gut.2011.240978. Epub 2011 Jun 27. PubMed PMID: 21708824.

  5. Vanuytsel T, Vermeire S, Cleynen I. The role of Haptoglobin and its related protein, Zonulin, in inflammatory bowel disease. Tissue Barriers. 2013 Dec 1;1(5):e27321. doi: 10.4161/tisb.27321. Epub 2013 Dec 10. Review. PubMed PMID: 24868498; PubMed Central PMCID: PMC3943850.

  6. Vardi M, Levy AP. Is it time to screen for the haptoglobin genotype to assess the cardiovascular risk profile and vitamin E therapy responsiveness in patients with diabetes? Curr Diab Rep. 2012 Jun;12(3):274-9. doi: 10.1007/s11892-012-0265-8. Review. PubMed PMID: 22427005; PubMed Central PMCID: PMC3590812.

  7. Wang S, Wang J, Zhang R, Wang T, Yan D, He Z, Jiang F, Hu C, Jia W. Mendelian randomization analysis to assess a causal effect of haptoglobin on macroangiopathy in Chinese type 2 diabetes patients. Cardiovasc Diabetol. 2018 Jan 16;17(1):14. doi: 10.1186/s12933-018-0662-7. PubMed PMID: 29338727; PubMed Central PMCID: PMC5769522.

KIF6

  1. Angelini S, Rosticci M, Massimo G, Musti M, Ravegnini G, Consolini N, Sammarini G, D’Addato S, Rizzoli E, Botbayev D, Borghi C, Cantelli-Forti G, Cicero AF, Hrelia P. Relationship between Lipid Phenotypes, Overweight, Lipid Lowering Drug Response and KIF6 and HMG-CoA Genotypes in a Subset of the Brisighella Heart Study Population. Int J Mol Sci. 2017 Dec 24;19(1). pii: E49. doi: 10.3390/ijms19010049. PubMed PMID: 29295555; PubMed Central PMCID: PMC5795999.

  2. Bale BF, Doneen AL. The Bale/Doneen Method: Paradigm Shift in CVD Prevention. Preceptorship Course; 2018 March 09; Las Vegas, Nevada, United States of America.

  3. Institute of Medicine. Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids. [Internet]. Washington, D.C.: National Academies Press; 2005. 941. Available from: https://www.nal.usda.gov/sites/default/files/fnic_uploads/energy_full_report.pdf. DOI: https://doi.org/10.17226/10490.

  4. Li Y, Iakoubova OA, Shiffman D, Devlin JJ, Forrester JS, Superko HR. KIF6 polymorphism as a predictor of risk of coronary events and of clinical event reduction by statin therapy. Am J Cardiol. 2010 Oct 1;106(7):994-8. doi: 10.1016/j.amjcard.2010.05.033. Epub 2010 Aug 11. Review. PubMed PMID: 20854963.

4Q25

  1. Bale BF, Doneen AL. The Bale/Doneen Method: Paradigm Shift in CVD Prevention. Preceptorship Course; 2018 March 09; Las Vegas, Nevada, United States of America.

  2. Isensee H, Jacob R. Differential effects of various oil diets on the risk of cardiac arrhythmias in rats. J Cardiovasc Risk. 1994 Dec;1(4):353-9. PubMed PMID: 7542556.

  3. Mortensen LM, Lundbye-Christensen S, Schmidt EB, Calder PC, Schierup MH, Tjønneland A, Parner ET, Overvad K. Long-chain n-3 and n-6 polyunsaturated fatty acids and risk of atrial fibrillation: Results from a Danish cohort study. PLoS One. 2017 Dec 22;12(12):e0190262. doi: 10.1371/journal.pone.0190262. eCollection 2017. PubMed PMID: 29272310; PubMed Central PMCID: PMC5741257.

  4. Rix TA, Joensen AM, Riahi S, Lundbye-Christensen S, Tjønneland A, Schmidt EB, Overvad K. A U-shaped association between consumption of marine n-3 fatty acids and development of atrial fibrillation/atrial flutter-a Danish cohort study. Europace. 2014 Nov;16(11):1554-61. doi: 10.1093/europace/euu019. Epub 2014 Feb 26. PubMed PMID: 24574493.

  5. Wu JH, Marchioli R, Silletta MG, Macchia A, Song X, Siscovick DS, Harris WS, Masson S, Latini R, Albert C, Brown NJ, Lamarra M, Favaloro RR, Mozaffarian D. Plasma phospholipid omega-3 fatty acids and incidence of postoperative atrial fibrillation in the OPERA trial. J Am Heart Assoc. 2013 Oct 21;2(5):e000397. doi: 10.1161/JAHA.113.000397. PubMed PMID: 24145742; PubMed Central PMCID: PMC3835252.

9P21

  1. Bale BF, Doneen AL. The Bale/Doneen Method: Paradigm Shift in CVD Prevention. Preceptorship Course; 2018 March 09; Las Vegas, Nevada, United States of America.

  2. Do R, Xie C, Zhang X, Männistö S, Harald K, Islam S, Bailey SD, Rangarajan S, McQueen MJ, Diaz R, Lisheng L, Wang X, Silander K, Peltonen L, Yusuf S, Salomaa V, Engert JC, Anand SS; INTERHEART investigators.. The effect of chromosome 9p21 variants on cardiovascular disease may be modified by dietary intake: evidence from a case/control and a prospective study. PLoS Med. 2011 Oct;8(10):e1001106. doi: 10.1371/journal.pmed.1001106. Epub 2011 Oct 11. PubMed PMID: 22022235; PubMed Central PMCID: PMC3191151.

  3. Hubacek JA, Vrablik M, Dlouha D, Stanek V, Gebauerova M, Adamkova V, Ceska R, Dostálová G, Linhart A, Vitek L, Pitha J. Gene variants at FTO, 9p21, and 2q36.3 are age-independently associated with myocardial infarction in Czech men. Clin Chim Acta. 2016 Feb 15;454:119-23. doi: 10.1016/j.cca.2016.01.005. Epub 2016 Jan 7. PubMed PMID: 26772723.

  4. Roberts R, Stewart AF. 9p21 and the genetic revolution for coronary artery disease. Clin Chem. 2012 Jan;58(1):104-12. doi: 10.1373/clinchem.2011.172759. Epub 2011 Oct 20. Review. PubMed PMID: 22015375.

  5. Yamagishi K, Folsom AR, Rosamond WD, Boerwinkle E; ARIC Investigators.. A genetic variant on chromosome 9p21 and incident heart failure in the ARIC study. Eur Heart J. 2009 May;30(10):1222-8. doi: 10.1093/eurheartj/ehp087. Epub 2009 Mar 26. PubMed PMID: 19329499; PubMed Central PMCID: PMC2682194.

  6. Zheng Y, Li Y, Huang T, Cheng HL, Campos H, Qi L. Sugar-sweetened beverage intake, chromosome 9p21 variants, and risk of myocardial infarction in Hispanics. Am J Clin Nutr. 2016 Apr;103(4):1179-84. PubMed PMID: 26961926; PubMed Central PMCID: PMC4807696.

Antinuclear Antibodies (ANA)

  1. Freed DL. Do dietary lectins cause disease? BMJ. 1999 Apr 17;318(7190):1023-4. PubMed PMID: 10205084; PubMed Central PMCID: PMC1115436.

  2. Kingeter LM, Lin X. C-type lectin receptor-induced NF-κB activation in innate immune and inflammatory responses. Cell Mol Immunol. 2012 Mar;9(2):105-12. doi: 10.1038/cmi.2011.58. Epub 2012 Jan 16. Review. PubMed PMID: 22246129; PubMed Central PMCID: PMC4002809.

  3. Li J, Yan H, Chen H, Ji Q, Huang S, Yang P, Liu Z, Yang B. The Pathogenesis of Rheumatoid Arthritis is Associated with Milk or Egg Allergy. N Am J Med Sci. 2016 Jan;8(1):40-6. doi: 10.4103/1947-2714.175206. PubMed PMID: 27011946; PubMed Central PMCID: PMC4784182.

  4. Li QZ, Karp DR, Quan J, Branch VK, Zhou J, Lian Y, Chong BF, Wakeland EK, Olsen NJ. Risk factors for ANA positivity in healthy persons. Arthritis Res Ther. 2011 Mar 2;13(2):R38. doi: 10.1186/ar3271. PubMed PMID: 21366908; PubMed Central PMCID: PMC3132017.

  5. Mora JR, Iwata M, von Andrian UH. Vitamin effects on the immune system: vitamins A and D take centre stage. Nat Rev Immunol. 2008 Sep;8(9):685-98. doi: 10.1038/nri2378. Review. PubMed PMID: 19172691; PubMed Central PMCID: PMC2906676.

  6. Safaie P, Ham M, Kuang P, Mehta AS, Wang M, Cheifetz AS, Robson S, Lau D, Block TM, Moss AC. Lectin-reactive anti-α-gal in patients with Crohn’s disease: correlation with clinical phenotypes. Inflamm Bowel Dis. 2013 Dec;19(13):2796-800. doi: 10.1097/01.MIB.0000435437.76741.cb. PubMed PMID: 24185312; PubMed Central PMCID: PMC4112456.

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